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HOW DOES CBD WORK?

CBD can be described as a ‘multitarget’ cannabinoid, meaning that it targets various systems and receptors in the body.10 The first target is the human endocannabinoid system or ECS.

THE HUMAN ENDOCANNABINOID SYSTEM (ECS)

WHAT IS THE ECS?

The endocannabinoid system (ECS) plays a key role in maintaining homeostasis (balance or equilibrium) in the body, connecting all of the body’s organs and systems.11

It is implicated in regulating many important physiological processes in the body such as mood, immunity, pain & inflammation, memory, neuroprotection appetite, bone growth, metabolism and movement17,18

HOW DOES THE ECS WORK?

Our body makes its own cannabinoids (endocannabinoids), which bind to cannabinoid receptors.17 Two major cannabinoid receptors, CB1 and CB2, and two main endocannabinoids, anandamide (AEA) and 2-arachidonoyl-glycerol (2-AG), have been identified.17

CB1

CB1 receptors are mainly located in the brain and central nervous system but are also found in other tissues such as the adrenals, liver, stomach, heart, lung, testes, prostate, uterus, ovary, bone marrow, thymus, tonsils and fat tissue17,19

CB2

CB2 receptors are most densely found in immunological tissues such as the spleen, tonsils and thymus, as well as parts of the nervous system.17

Adapted from Nathigal I, et al; 201617

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